The heterogeneity of target recognition by lymphokine-activated killer precursor cells.

Lymphokine-activated killer (LAK) cells were generated from peripheral blood lymphocytes (PBL) that were depleted of mature cytotoxic natural killer (NK) cells. PBL NK activity was abolished by pretreatment of effector cells with the toxic lysosomotropic agent L-leucine methyl ester (LME) or by depletion of effector cells by K562 monolayer absorption (MA). Both treatments markedly reduced the proportion of cells expressing NK-associated markers such as CD 16 (Leu 11b, B73.1), Leu 7, and NKH-1 (Leu 19), whereas these treatments had minimal effects on cells expressing T cell markers (CD 3, CD 4, and CD 8). LME and MA also drastically decreased the proportion of K562 target-binding lymphocytes. LAK activity against NK-sensitive and NK-resistant targets can be generated from the NK cell-depleted PBL by incubation with interleukin-2. Peak LAK activity generated from MA-treated PBL was later than the peak of LAK activity generated from either untreated or LME-treated PBL. Although MA of PBL on NK-resistant S4 sarcoma targets had little effect on NK activity, LAK activity against both K562 and S4 targets was reduced. These results suggest that there are at least three LAK precursor subpopulations in PBL: mature NK cells that can bind and kill K562 targets (LME-sensitive and MA-sensitive); "pre-NK" cells that can bind but cannot kill (LME-resistant and MA-sensitive); and non-NK cells that cannot bind and cannot kill K562 targets (MA-resistant)

Development of a 66 kV-5 kA Class HTS Power Cable with IBAD/PLD REBCO Tapes

AbstractHigh temperature superconducting (HTS) cables are able to achieve large power capacity and low-loss power transmission. In the Japanese national project, Fujikura Ltd. worked on developing a 66 kV-5 kArms HTS power cable using high critical current (Ic) REBa2Cu3Ox (REBCO, RE = rare earth) tapes. One of the technical targets in this project is to reduce AC loss to less than 2W/m at 5 kArms. The REBCO tapes with 240 A/4mm-width of Ic at 77K, self field, which were fabricated by Ion-beam-assisted-deposition (IBAD) and Pulsed Laser Deposition (PLD) method, were applied to a HTS power cable in order to achieve extremely low AC loss. As a result, we have succeeded in developing a 20 m-long 66 kV-5 kArms HTS power cable. The measured AC loss was achieved 1.4W/m at 77K and 1.0W/m at 67K at 5 kArms

Structural analysis and magnetic properties of Fe/Bi system

Abstract We have investigated the structure and magnetic properties of Fe/Bi multilayers and trilayers by RHEED, XRD,XRR,XPS and SQUID. The samples were grown by molecular beam epitaxy method. It was found that the synthesis of the multiplayer is very difficult. However, we successfully grown Fe/Bi trilayers by adopting the appropriate growth conditions. Key words: magnetic multiplayer; MBE; Magnetization; X-ray reflectivity It has been known that Fe-based intermetallic compounds show a variety of magnetic properties. Many kinds of magnetism such as Ferromagnetism, Antiferromagnetism and itinerant metamagnetism have been observed, depending on the constituent elements and crystal structures. In case of Fe monopnictides, FeP and FeAs show spiral magnetic states, and FeSb antiferromagnetism. However, there has been no report on FeBi, because Fe and Bi are immiscible in the equilibrium states and neither alloy nor intermetallic compound exists in the binary system Only a few studies have been reported for Fe/Bi film systems. The crystal structure of both metals differ from each other so markedly, that polycrystalline and amorphous Fe/Bi multilayers have been grown onto cooled substrate. Thickness dependence of saturation magnetization has been studied Samples were prepared by alternate deposition of Fe and Bi on SrTiO3(100) STO substrates in an ultrahigh vacuum, which is order of 10 −9 Torr. The substrate temperature was varied in wide temperature range from room temperature up to 523K. Multilayered films were prepared with a fixed Fe layer thickness, i.e., STO/[Fe(50Å)/Bi(tBi)]*20 (tBi = 5, 10, 20, 36 and 60Å). The top Bi layer was deposited as cover layer to prevent oxidation. The first Fe layer was deposited as a buffer. On the other hand, trilayered samples were prepared; fixed Fe layer thickness, STO/Fe(500Å)/Bi(tBi)/Fe(500Å) (tBi = 50, 150, and 300Å). Total thickness of Fe was fixed to be 1000Å. The crystallographic structures of the prepared samples were characterized by X-ray diffraction using CuKα radiation with the scattering vector perpendicular to the film plane. Magnetization measurements were performed by a SQUID magnetometer. At first, we prepared Fe/Bi multilayers. High-angle X-ray pattern shows clear Bragg reflections of the Bi(012) and Fe(200). However, the low-angle reflected pattern and satellite peaks from the multilayerd

Endoscopic Management of Gastric Polyp with Outlet Obstruction without Polypectomy

Although gastric polyp is usually an incidental endoscopic finding, large-sized polyps can cause symptoms ranging from epigastralgia to bleeding from ulcerated polyps and gastric outlet obstruction. Although the gold standard of treatment is removal of the polyp either through endoscopic polypectomy or surgical excision, complications associated with these procedures cannot be ignored. The risk becomes a major concern for patients at high risk for surgery when complications arise. We describe a debilitated 74-year-old woman who presented with early satiety, intermittent postprandial nausea and vomiting for three months. Upper endoscopy revealed a 2.5 cm pedunculated polyp over the gastric antrum causing intermittent obstruction. Considering her high risk for polypectomy, detachable snaring was performed without polypectomy in an outpatient setting. The patient was complication-free with complete relief of obstructive symptoms one week after the procedure. Subsequent follow-ups showed satisfactory healing without signs of mucosal disruption or recurrence. The results suggest that detachable snaring without polypectomy may be a therapeutic option for high-risk patients with benign symptomatic gastric polyps

HE-LHC: The High-Energy Large Hadron Collider – Future Circular Collider Conceptual Design Report Volume 4

In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries

FCC Physics Opportunities: Future Circular Collider Conceptual Design Report Volume 1

We review the physics opportunities of the Future Circular Collider, covering its e+e-, pp, ep and heavy ion programmes. We describe the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions, the top quark and flavour, as well as phenomena beyond the Standard Model. We highlight the synergy and complementarity of the different colliders, which will contribute to a uniquely coherent and ambitious research programme, providing an unmatchable combination of precision and sensitivity to new physics

FCC-ee: The Lepton Collider: Future Circular Collider Conceptual Design Report Volume 2

In response to the 2013 Update of the European Strategy for Particle Physics, the Future Circular Collider (FCC) study was launched, as an international collaboration hosted by CERN. This study covers a highest-luminosity high-energy lepton collider (FCC-ee) and an energy-frontier hadron collider (FCC-hh), which could, successively, be installed in the same 100 km tunnel. The scientific capabilities of the integrated FCC programme would serve the worldwide community throughout the 21st century. The FCC study also investigates an LHC energy upgrade, using FCC-hh technology. This document constitutes the second volume of the FCC Conceptual Design Report, devoted to the electron-positron collider FCC-ee. After summarizing the physics discovery opportunities, it presents the accelerator design, performance reach, a staged operation scenario, the underlying technologies, civil engineering, technical infrastructure, and an implementation plan. FCC-ee can be built with today’s technology. Most of the FCC-ee infrastructure could be reused for FCC-hh. Combining concepts from past and present lepton colliders and adding a few novel elements, the FCC-ee design promises outstandingly high luminosity. This will make the FCC-ee a unique precision instrument to study the heaviest known particles (Z, W and H bosons and the top quark), offering great direct and indirect sensitivity to new physics